22 Hour Drive… Need Advice, Tips, Etc?

We’ve made the drive several times w/ one baby/ child but never with two. [Ahhh!] I sent my father-in-law a text video of the boys this past weekend and within 5 minutes he called begging us to come up to visit and told us a check for fuel was in the mail. We have a 3 1/2 year old and a 6 month old. Last time we left around 8pm and our 3 year old slept all night and we made some good time. Would you do the same thing or just leave in the morning and get a hotel room? Which would be better and why? (If we left at night we could alternate sleeping so that’s not a big deal.) Time and money isn’t a huge issue, I just want to do what is best for the boys sake so that they aren’t too uncomfortable. Thanks!